Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis

Academic Article


  • Salicylates were administered to 6 patients with juvenile rheumatoid arthritis in doses sufficient to produce a serum salicylate level in excess of 25 mg/100 ml. All 6 patients developed elevations of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase. In addition, 4 patients had other evidence of hepatic dysfunction. Abnormalities were dose‐related and were reversible upon lowering the salicylate dose. Liver biopsies performed in 2 patients revealed a mononuclear cell infiltrate of portal triads in both and scattered single cell necrosis in the parenchyma in 1 case. Copyright © 1973 American College of Rheumatology
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    Author List

  • Rich RR; Johnson JS
  • Start Page

  • 1
  • End Page

  • 9
  • Volume

  • 16
  • Issue

  • 1