© 2015 by John Wiley & Sons, Inc.. All rights reserved. Zygomatic implants were designed by Per-Ingvar Brånemark to allow for implant-supported prosthesis placement where maxillary bony support for prosthetic rehabilitation is inadequate. This chapter discusses in detail the indications, contraindications, original surgical technique, postoperative management, intrasurgical and postoperative complications of zygomatic implants. It describes the anatomy of the zygoma bone and the implant anatomy. Numerous companies have designed and market zygomatic implants worldwide. The implant most commonly used in the United States is available in eight different lengths (30, 35, 40, 42.5, 45, 47.5, 50, and 52.5). The chapter discusses the special considerations when placing two ipsilateral zygomatic implants. It also describes several modifications such as sinus slot technique, immediate loading and zygoma anatomy-guided approach (ZAGA) of the original protocol. Finally, it presents a case report of a 74-year-old male with a severely atrophic maxilla.