Stroke symptoms and risk for incident coronary heart disease in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study

Academic Article

Abstract

  • © 2016 Elsevier Ireland Ltd Background Many adults without cerebrovascular disease report a history of stroke symptoms, which is associated with higher risk for stroke. Because stroke and coronary heart disease (CHD) share many risk factors, we examined the association between a history of stroke symptoms and incident CHD. Methods We analyzed data from 8999 black and 12,499 white REasons for Geographic And Racial Differences in Stroke (REGARDS) study participants without a prior myocardial infarction, stroke or transitory ischemic attack enrolled in 2003–2007 (total participants = 21,498, all ≥ 45 years of age). A history of stroke symptoms (i.e., unilateral weakness, unilateral numbness, full-field vision loss, half-field vision loss, understanding problems and communication problems) was assessed at baseline using the Questionnaire for Verifying Stroke-Free Status. Participants were followed for incident CHD and CHD death through December 2011. Results Overall, 3432 (16.0%) participants reported a history of stroke symptoms (1771 [19.7%] blacks and 1661 [13.3%] whites). There were 701 incident CHD events including 209 CHD deaths over a median follow-up of 5.8 years. After adjustment for CHD risk factors, hazard ratios (95% confidence interval [95% CI]) for incident CHD associated with reporting any versus no stroke symptoms were 1.26 (1.04–1.51) in the overall population, 1.28 (0.99–1.65) among blacks and 1.23 (0.94–1.61) among whites. Multivariable-adjusted hazard ratios (95% CI) for CHD death associated with any versus no stroke symptoms were 1.50 (1.10–2.06) overall, 1.58 (1.07–2.32) among blacks and 1.41 (0.82–2.43) among whites. Conclusion A history of stroke symptoms is associated with a higher incidence of CHD among black and white adults.
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    Author List

  • Colantonio LD; Gamboa CM; Kleindorfer DO; Carson AP; Howard VJ; Muntner P; Cushman M; Howard G; Safford MM
  • Start Page

  • 122
  • End Page

  • 128
  • Volume

  • 220