Environmental contaminants and body fat distribution.

Academic Article

Abstract

  • The effect of body mass index (BMI) and waist:hip ratio (WHR) on plasma levels of organochlorines [i.e., 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE)] was investigated in a sample of black and white women drawn from a population-based study in North Carolina. Organochlorine levels were determined in plasma samples from 99 women selected on the basis of race (black versus white) and quartile of the WHR (1st versus 4th). Of a panel of 20 organochlorine compounds tested, only DDE was detectable in most study subjects. Measurements of height, weight, and waist and hip circumferences were taken during an in-person interview. Information was elicited regarding dietary, residential, and breast-feeding histories. Results of multiple regression analyses indicate that black women had significantly higher plasma levels of DDE than white women. These levels were independent of BMI and WHR. BMI but not WHR was also found to be an independent predictor of DDE plasma level. These results suggest that black/white differences should be considered in studies that explore the relationship between environmental contaminants and various disease outcomes, such as breast cancer risk. In addition, BMI may affect circulating levels of contaminants and should also be considered a potentially important modifying factor for exposure to lipophilic substances.
  • Keywords

  • African Continental Ancestry Group, Aged, Analysis of Variance, Body Constitution, Body Height, Body Mass Index, Body Weight, Breast Feeding, Breast Neoplasms, Dichlorodiphenyl Dichloroethylene, Diet, Environmental Pollutants, European Continental Ancestry Group, Female, Forecasting, Humans, Insecticides, Middle Aged, North Carolina, Regression Analysis, Residence Characteristics, Risk Factors
  • Author List

  • Schildkraut JM; Demark-Wahnefried W; DeVoto E; Hughes C; Laseter JL; Newman B
  • Start Page

  • 179
  • End Page

  • 183
  • Volume

  • 8
  • Issue

  • 2