Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

Academic Article

Abstract

  • Methods: We performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like ALL. We examined the functional effects of fusion proteins and the efficacy of tyrosine kinase inhibitors in mouse pre-B cells and xenografts of human Ph-like ALL.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Roberts KG; Li Y; Payne-Turner D; Harvey RC; Yang YL; Pei D; McCastlain K; Ding L; Lu C; Song G
  • Start Page

  • 1005
  • End Page

  • 1015
  • Volume

  • 371
  • Issue

  • 11