Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants.

Academic Article


  • CONTEXT: Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures. OBJECTIVE: To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers. METHODS: In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models. RESULTS: Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated. CONCLUSIONS: Different biomarkers of oxidative stress may reflect different biological processes.
  • Authors

    Published In

  • Biomarkers  Journal
  • Keywords

  • Oxidative balance, oxidative stress, race, Adult, Africa, Western, African Americans, Biomarkers, Carotenoids, Cross-Sectional Studies, Cryptoxanthins, DNA, Mitochondrial, Diet, European Continental Ancestry Group, Gene Dosage, Humans, Isoprostanes, Lycopene, Middle Aged, Oxidative Stress, Sensitivity and Specificity, Zeaxanthins, beta Carotene
  • Digital Object Identifier (doi)

    Author List

  • Lakkur S; Bostick RM; Roblin D; Ndirangu M; Okosun I; Annor F; Judd S; Dana Flanders W; Stevens VL; Goodman M
  • Start Page

  • 471
  • End Page

  • 480
  • Volume

  • 19
  • Issue

  • 6