Systemic inflammatory response syndrome in tissue-type plasminogen activator-treated patients is associated with worse short-term functional outcome.

Academic Article


  • BACKGROUND AND PURPOSE: Systemic inflammatory response syndrome (SIRS) is a generalized inflammatory state. The primary goal of the study was to determine whether differences exist in outcomes in SIRS and non-SIRS intravenous tissue-type plasminogen activator-treated patients. METHODS: Consecutive patients were retrospectively reviewed for the evidence of SIRS during their admission. SIRS was defined as the presence of ≥2 of the following: body temperature<36°C or >38°C, heart rate>90, respiratory rate>20, and white blood cells<4000/mm or >12 000 mm, or >10% bands. Patients diagnosed with infection (via positive culture) were excluded. RESULTS: Of the 241 patients, 44 had evidence of SIRS (18%). Adjusting for pre-tissue-type plasminogen activator National Institutes of Health Stroke Scale, age, and race, SIRS remained a predictor of poor functional outcome at discharge (odds ratio [OR], 2.58; 95% confidence interval [CI], 1.16-5.73; P=0.0197). CONCLUSIONS: In our sample of tissue-type plasminogen activator-treated (tPA) patients, ~1 in 5 patients developed SIRS. Furthermore, we found the presence of SIRS to be associated with poor short-term functional outcomes and prolonged length of stay.
  • Published In

  • Stroke  Journal
  • Keywords

  • inflammation, ischemic stroke, stroke care, tPA, Administration, Intravenous, Adult, Aged, Aged, 80 and over, Female, Fibrinolytic Agents, Humans, Length of Stay, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Systemic Inflammatory Response Syndrome, Thrombolytic Therapy, Time Factors, Tissue Plasminogen Activator, Treatment Outcome, Young Adult
  • Digital Object Identifier (doi)

    Pubmed Id

  • 2645957
  • Author List

  • Boehme AK; Kapoor N; Albright KC; Lyerly MJ; Rawal PV; Bavarsad Shahripour R; Alvi M; Houston JT; Sisson A; Beasley TM
  • Start Page

  • 2321
  • End Page

  • 2323
  • Volume

  • 44
  • Issue

  • 8