Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.

Academic Article

Abstract

  • Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood. These data contrast with observations in the 2012 NIA intramural study report, where a difference in survival was not detected between control-fed and CR monkeys. A comparison of body weight of control animals from both studies with each other, and against data collected in a multi-centred relational database of primate ageing, suggests that the NIA control monkeys were effectively undergoing CR. Our data indicate that the benefits of CR on ageing are conserved in primates.
  • Published In

    Keywords

  • Aging, Animals, Body Weight, Caloric Restriction, Disease Models, Animal, Female, Humans, Longevity, Macaca mulatta, Male, Mortality, Survival Analysis
  • Digital Object Identifier (doi)

    Pubmed Id

  • 9827894
  • Author List

  • Colman RJ; Beasley TM; Kemnitz JW; Johnson SC; Weindruch R; Anderson RM
  • Start Page

  • 3557
  • Volume

  • 5