Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites.

Academic Article


  • To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
  • Published In

  • AIDS  Journal
  • Keywords

  • Age Factors, Atherosclerosis, Carotid Intima-Media Thickness, Case-Control Studies, European Continental Ancestry Group, HIV Infections, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Ryanodine Receptor Calcium Release Channel
  • Digital Object Identifier (doi)

    Author List

  • Shrestha S; Yan Q; Joseph G; Arnett DK; Martinson JJ; Kingsley LA
  • Start Page

  • 1571
  • End Page

  • 1573
  • Volume

  • 26
  • Issue

  • 12