Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey.

Academic Article


  • BACKGROUND: The prevalences of both hypertension and vitamin D insufficiency are high in the United States. Recent clinical trials and animal studies have suggested that vitamin D insufficiency may be associated with elevated blood pressure. OBJECTIVE: With cross-sectional data, we sought to determine whether vitamin D concentrations were related to systolic blood pressure (SBP) in the third National Health and Nutrition Examination Survey (1988-1992). DESIGN: Blood pressure was classified with 5 categories from the Joint National Committee 7 with a sixth category added to distinguish participants with normotensive SBP (<110 mm Hg) from those with high-normal SBP (110-119 mm Hg). We used predicted marginals to estimate the conditional means of serum 25 hydroxyvitamin D [25(OH)D] and to test for trend across blood pressure categories. We used linear regression to explore the association between vitamin D, blood pressure, and age. RESULTS: Lower 25(OH)D concentrations were associated with a higher blood pressure category in whites (P<0.001); however, when controlling for age, the association was no longer significant. Concentrations of 25(OH)D>80 nmol/L decreased the age-related increase in SBP by 20% compared with participants having 25(OH)D concentrations<50 nmol/L (P<0.001). Only 8% of blacks had 25(OH)D concentrations>80 nmol/L. CONCLUSIONS: SBP is inversely associated with serum vitamin D concentrations in nonhypertensive white persons in the United States. This observation provides a rationale for studies on the potential effects of vitamin D supplementation as a method to reduce SBP in persons at risk of hypertension.
  • Authors


  • Adult, Aged, Aging, Blood Pressure, Bone Density Conservation Agents, Comorbidity, Cross-Sectional Studies, European Continental Ancestry Group, Female, Humans, Hypertension, Linear Models, Male, Middle Aged, Nutrition Surveys, Nutritional Status, Seasons, Systole, Vitamin D, Vitamin D Deficiency
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    Author List

  • Judd SE; Nanes MS; Ziegler TR; Wilson PWF; Tangpricha V
  • Start Page

  • 136
  • End Page

  • 141
  • Volume

  • 87
  • Issue

  • 1