Risk factors for vitamin D deficiency and relationship with cardiac biomarkers, inflammation and immune restoration in HIV-infected youth.

Academic Article

Abstract

  • BACKGROUND: Vitamin D deficiency is common in HIV-infected individuals. In adults, traditional and HIV-related factors play a role in vitamin D status, and deficiency appears to impair immune restoration and exacerbate HIV complications, like cardiovascular disease (CVD). This study sought to determine factors contributing to vitamin D status in HIV-infected youth and investigate the relationship with CVD risk, inflammation and immune restoration. METHODS: HIV-infected subjects (1-25 years old) were enrolled prospectively along with healthy controls that were group-matched by age, sex and race. HIV data were collected for the HIV-infected group, while traditional risk factors, including vitamin D intake, sun exposure, skin pigmentation, physical activity level and body mass index (BMI) were collected for both groups. Fasting lipids, plasma 25-hydroxyvitamin D (25[OH]D), and inflammation markers were measured. RESULTS: In total, 200 HIV-infected subjects and 50 controls were enrolled. HIV group had 53% male, 95% Black and a mean age of 17.2 ±4.6 years. There was no difference in 25(OH)D between groups; 77% of HIV+ and 74% of controls had 25(OH)D<20 ng/ml. Only Fitzpatrick skin type was independently associated with 25(OH)D. No HIV variables were associated with 25(OH)D, even when HIV sub-populations were examined. Inflammation, CVD risk factors and immune restoration were not independently associated with 25(OH)D. CONCLUSIONS: Vitamin D deficiency is common among HIV-infected youth. However, HIV factors, CVD risk, inflammation and immune restoration do not appear to have the same relationship with vitamin D as has been shown in adults. Supplementation trials are needed to determine if increasing 25(OH)D concentrations could better elucidate these relationships.
  • Authors

    Published In

  • Antiviral Therapy  Journal
  • Keywords

  • Adolescent, Biomarkers, Body Mass Index, CD4 Lymphocyte Count, Cardiovascular Diseases, Case-Control Studies, Cross-Sectional Studies, Cytokines, Female, HIV, HIV Infections, Humans, Inflammation, Male, Motor Activity, Prospective Studies, RNA, Viral, Risk Factors, Sunlight, Vitamin D, Vitamin D Deficiency, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Eckard AR; Judd SE; Ziegler TR; Camacho-Gonzalez AF; Fitzpatrick AM; Hadley GR; Grossmann RE; Seaton L; Seydafkan S; Mulligan MJ
  • Start Page

  • 1069
  • End Page

  • 1078
  • Volume

  • 17
  • Issue

  • 6