Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum

Academic Article

Abstract

  • The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.
  • Authors

    Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Wilson CM; Serrano AE; Wasley A; Bogenschutz MP; Shankar AH; Wirth DF
  • Start Page

  • 1184
  • End Page

  • 1186
  • Volume

  • 244
  • Issue

  • 4909