Interleukin-10 gene (IL10) polymorphisms and human papillomavirus clearance among immunosuppressed adolescents.

Academic Article


  • Persistent infection with high-risk human papillomavirus (HPV) is a major risk factor for cervical cancer, and HPV clearance seems to be under host genetic influence. This study evaluated associations between three single nucleotide polymorphisms in the IL10 promoter and clearance of low- or high-risk HPV infection in a cohort of 226 largely HIV-1-infected African-American adolescent females. Among immunosuppressed individuals (HIV-1 seropositive and CD4(+)
  • Keywords

  • Adolescent, Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Child, Cohort Studies, Cytosine, Female, Follow-Up Studies, Guanine, HIV Infections, HIV Seronegativity, HIV Seropositivity, HIV-1, Haplotypes, Human papillomavirus 16, Human papillomavirus 18, Humans, Immunocompromised Host, Interleukin-10, Papillomavirus Infections, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Risk Factors
  • Digital Object Identifier (doi)

    Author List

  • Shrestha S; Wang C; Aissani B; Wilson CM; Tang J; Kaslow RA
  • Start Page

  • 1626
  • End Page

  • 1632
  • Volume

  • 16
  • Issue

  • 8