The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans.

Academic Article

Abstract

  • Populations of African ancestry continue to account for a disproportionate burden of the human immunodeficiency virus type 1 (HIV-1) epidemic in the United States. We investigated the effects of human leukocyte antigen (HLA) class I markers in association with virologic and immunologic control of HIV-1 infection among 338 HIV-1 subtype B-infected African Americans in 2 cohorts: Reaching for Excellence in Adolescent Care and Health (REACH) and HIV Epidemiology Research Study (HERS). One-year treatment-free interval measurements of HIV-1 RNA viral loads and CD4(+) T cells were examined both separately and combined to represent 3 categories of HIV-1 disease control (76 controllers, 169 intermediates, and 93 noncontrollers). Certain previously or newly implicated HLA class I alleles (A*32, A*36, A*74, B*14, B*1510, B*3501, B*45, B*53, B*57, Cw*04, Cw*08, Cw*12, and Cw*18) were associated with 1 or more of the endpoints in univariate analyses. After multivariable adjustments for other genetic and nongenetic risk factors of HIV-1 progression, the subset of alleles more strongly or consistently associated with HIV-1 disease control included A*32, A*74, B*14, B*45, B*53, B*57, and Cw*08. Carriage of infrequent HLA-B but not HLA-A alleles was associated with more favorable disease outcomes. Certain HLA class I associations with control of HIV-1 infection cross the boundaries of race and viral subtype, whereas others appear confined within one or the other of those boundaries.
  • Published In

  • Human Immunology  Journal
  • Keywords

  • Adolescent, Adult, African Americans, Alleles, CD4 Lymphocyte Count, Female, Gene Frequency, Genetic Association Studies, HIV Infections, HIV-1, Histocompatibility Antigens Class I, Humans, Linkage Disequilibrium, Male, Middle Aged, Viral Load, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Lazaryan A; Song W; Lobashevsky E; Tang J; Shrestha S; Zhang K; McNicholl JM; Gardner LI; Wilson CM; Klein RS
  • Start Page

  • 312
  • End Page

  • 318
  • Volume

  • 72
  • Issue

  • 4