Haematological response to iron supplementation is reduced in children with asymptomatic Helicobacter pylori infection

Academic Article

Abstract

  • We evaluated the adverse effect of asymptomatic Helicobacter pylori infection in children on the response to Fe supplementation. One hundred and sixty-nine children aged 1-10 years from the urban poor community underwent a [13C]urea breath test for H. pylori and haematological tests at admission and after 8 weeks. Both H. pylori-positive and -negative children were randomly assigned to receive ferrous fumarate syrup (20 mg elemental Fe twice daily) or placebo for 8 weeks and a single dose of vitamin A (33,000 μg). Admission findings were compared between H. pylori-positive and -negative children. Response to Fe was compared between Fe-supplemented H. pylori-positive and -negative children. Seventy-nine per cent of the children were aged 1-5 years and half of them were boys. In eighty-five H. pylori-positive and eighty-four H. pylori-negative children, the differences in mean Hb (112 (SD 12.6) v. 113 (SD 12.0) g/l), haematocrit (34 (SD 3.5) v. 35 (SD 3.2) %) and ferritin (23.8 v. 21.0 μg/l) were similar. After 8 weeks of Fe supplementation, mean Hb was 5.3 g/l more (95 % CI 1.59, 9.0) and haematocrit was 1.4 % more (95 % CI 0.2, 2.6) in H. pylori-negative (n 44) compared with H. pylori-positive (n 42) children. Mean ferritin was similar at admission and improved in both H. pylori-positive and -negative children. Asymptomatic H. pylori infection was not associated with higher rates of anaemia or Fe deficiency in children, but had a significant adverse effect on response to Fe therapy. However, this result is based on exploratory analysis and needs confirmation. © The Authors 2005.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Mahalanabis D; Islam MA; Shaikh S; Chakrabarty M; Kurpad AV; Mukherjee S; Sen B; Khaled MA; Varmund SH
  • Start Page

  • 969
  • End Page

  • 975
  • Volume

  • 94
  • Issue

  • 6