© 2015 Revista Latino-Americana de Enfermagem. Objective: to test a theoretical model based on the Parent-Based Expansion of the Theory of Planned Behavior examining relation between selected parental, teenager and cultural variables and Latino teenagers’ intentions to engage in sexual behavior. Method: a cross-sectional correlational design based on a secondary data analysis of 130 Latino parent and teenager dyads. Results: regression and path analysis procedures were used to test seven hypotheses and the results demonstrated partial support for the model. Parent familism and knowledge about sex were significantly associated with parents’ attitudes toward sexual communication with their teenagers. Parent Latino acculturation was negatively associated with parents’ self-efficacy toward sexual communication with their teenagers and positevely associated with parents’ subjective norms toward sexual communication with their teenagers. Teenager knowledge about sex was significantly associated with higher levels of teenagers’ attitudes and subjective norms about sexual communication with parents. Only the predictor of teenagers’ attitudes toward having sex in the next 3 months was significantly associated with teenagers’ intentions to have sex in the next 3 months. Conclusion: the results of this study provide important information to guide future research that can inform development of interventions to prevent risky teenager sexual behavior among Latinos.