Caloric restriction delays disease onset and mortality in rhesus monkeys.

Academic Article

Abstract

  • Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.
  • Published In

  • Science  Journal
  • Keywords

  • Aging, Animals, Atrophy, Body Weight, Brain, Caloric Restriction, Cardiovascular Diseases, Diabetes Mellitus, Female, Glucose, Incidence, Longevity, Macaca mulatta, Male, Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Colman RJ; Anderson RM; Johnson SC; Kastman EK; Kosmatka KJ; Beasley TM; Allison DB; Cruzen C; Simmons HA; Kemnitz JW
  • Start Page

  • 201
  • End Page

  • 204
  • Volume

  • 325
  • Issue

  • 5937