Association of glycemic load with cardiovascular disease risk factors: The Women's Health Initiative Observational Study

Academic Article

Abstract

  • Objective: Associations between dietary glycemic load (GL) and cardiovascular disease risk factors, including plasma lipoprotein/lipid levels, blood pressure, and glucose metabolism factors, in the Women's Health Initiative Observational Study were examined. Methods: A random sample of 878 Observational Study participants (postmenopausal women 50-79 y of age) with baseline blood measurements (647 white, 104 black, 127 Hispanic) was included. Dietary GL was estimated from baseline food-frequency questionnaires, which assessed dietary intake over the previous 3 mo. At the baseline visit, participants completed demographic and health habit questionnaires, fasting blood samples were collected, anthropometric measurements were completed, and blood pressure was assessed. Results: In all participants combined, GL was inversely associated with high-density lipoprotein cholesterol (P for trend = 0.004) and positively associated with log10-transformed triacylglycerols (P = 0.008). Although there were no statistically significant interactions of race/ethnicity with associations between GL and cardiovascular disease risk factors, stratified results were suggestive, showing that GL was positively associated with total cholesterol (P = 0.018) and low-density lipoprotein cholesterol (P = 0.038) in Hispanics. In white subjects, there was a trend of reduced high-density lipoprotein cholesterol with higher GL (P = 0.003), whereas GL was positively associated with log10-transformed triacylglycerols (P = 0.015). Associations between GL and high-density lipoprotein cholesterol and between GL and triacylglycerols also differed by body mass index, although the interactions were not statistically significant. Conclusion: Among these generally healthy postmenopausal women, GL was associated with high-density lipoprotein cholesterol and triacylglycerols. Suggestive effects of race/ethnicity and body mass index on these associations need to be confirmed in larger studies. © 2010 Elsevier Inc.
  • Published In

  • Nutrition  Journal
  • Digital Object Identifier (doi)

    Author List

  • Shikany JM; Tinker LF; Neuhouser ML; Ma Y; Patterson RE; Phillips LS; Liu S; Redden DT
  • Start Page

  • 641
  • End Page

  • 647
  • Volume

  • 26
  • Issue

  • 6