An Internet-based Controlled Trial Aimed to Improve Osteoporosis Prevention among Chronic Glucocorticoid Users.

Academic Article


  • OBJECTIVE: To address the low prevention and treatment rates for those at risk of glucocorticoid-induced osteoporosis (GIOP), we evaluated the influence of a direct-to-patient, Internet-based educational video intervention using "storytelling" on rates of antiosteoporosis medication use among chronic glucocorticoid users who were members of an online pharmacy refill service. METHODS: We identified members who refilled ≥ 5 mg/day of prednisone (or equivalent) for 90 contiguous days and had no GIOP therapy for ≥ 12 months. Using patient stories, we developed an online video addressing risk factors and treatment options, and delivered it to members refilling a glucocorticoid prescription. The intervention consisted of two 45-day "Video ON" periods, during which the video automatically appeared at the time of refill, and two 45-day "Video OFF" periods, during which there was no video. Members could also "self-initiate" watching the video by going to the video link. We used an interrupted time series design to evaluate the effectiveness of this intervention on GIOP prescription therapies over 6 months. RESULTS: Among 3017 members (64.8%) exposed to the intervention, 59% had measurable video viewing time, of which 3% "self-initiated" the video. The GIOP prescription rate in the "Video ON" group was 2.9% versus 2.7% for the "Video OFF" group. There was a nonsignificant trend toward greater GIOP prescription in members who self-initiated the video versus automated viewing (5.7% vs 2.9%, p = 0.1). CONCLUSION: Among adults at high risk of GIOP, prescription rates were not significantly affected by an online educational video presented at the time of glucocorticoid refill. Identifier: NCT01378689.
  • Published In


  • GLUCOCORTICOID-INDUCED OSTEOPOROSIS, INTERNET, PATIENT COMPLIANCE, Adult, Aged, Aged, 80 and over, Bone Density, Female, Glucocorticoids, Humans, Middle Aged, Osteoporosis
  • Digital Object Identifier (doi)

    Author List

  • Warriner AH; Outman RC; Allison JJ; Curtis JR; Markward NJ; Redden DT; Safford MM; Stanek EJ; Steinkellner AR; Saag KG
  • Start Page

  • 1478
  • End Page

  • 1483
  • Volume

  • 42
  • Issue

  • 8