Effect of oral estrogen on substrate utilization in postmenopausal women.

Academic Article

Abstract

  • We tested the hypothesis that a 2-month intervention with unopposed oral conjugated equine estrogens (0.625 mg/d) would decrease lipid oxidation, as assessed by 24-hour, whole-room, indirect calorimetry in 14 postmenopausal women. Estrogen (E) treatment was associated with declines in both 24-hour and postprandial lipid oxidation and an increase in fat mass (mean [+/-SD] 2-month difference 1.1 +/- 1.0 kg; mean 6-month difference 1.8 +/- 2.2 kg), suggesting that, on an acute basis, oral E may increase adiposity by limiting lipid oxidation.
  • Published In

    Keywords

  • Administration, Oral, Dose-Response Relationship, Drug, Estrogens, Female, Hormone Replacement Therapy, Humans, Lipid Metabolism, Lipid Peroxidation, Middle Aged, Postmenopause
  • Digital Object Identifier (doi)

    Author List

  • Lwin R; Darnell B; Oster R; Lawrence J; Foster J; Azziz R; Gower BA
  • Start Page

  • 1275
  • End Page

  • 1278
  • Volume

  • 90
  • Issue

  • 4