Genes and environment in neonatal intraventricular hemorrhage.

Academic Article

Abstract

  • Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
  • Published In

    Keywords

  • GWAS, genes, intraventricular hemorrhage, neonate, preterm, Apgar Score, Cerebral Ventricles, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Intracranial Hemorrhages, Pregnancy, Risk Factors, United States
  • Digital Object Identifier (doi)

    Author List

  • Ment LR; Ådén U; Bauer CR; Bada HS; Carlo WA; Kaiser JR; Lin A; Cotten CM; Murray J; Page G
  • Start Page

  • 592
  • End Page

  • 603
  • Volume

  • 39
  • Issue

  • 8