Genes and environment in neonatal intraventricular hemorrhage

Academic Article

Abstract

  • © 2015 Elsevier Inc. Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ment LR; Ådén U; Bauer CR; Bada HS; Carlo WA; Kaiser JR; Lin A; Cotten CM; Murray J; Page G
  • Start Page

  • 592
  • End Page

  • 603
  • Volume

  • 39
  • Issue

  • 8