Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system

Academic Article


  • Growth hormone plays an important role in regulating numerous functions in vertebrates. Several pathways that negatively regulate the magnitude and duration of its signaling (including expression of tyrosine phosphatases, SOCS and PIAS proteins) are shared between signaling induced by growth hormone itself and by other cytokines. Here we overview downregulation of the growth hormone receptor as the most specific and potent mechanism of restricting cellular responses to growth hormone and analyze the role of several proteolytic systems and, specifically, ubiquitin-dependent pathways in this regulation. © 2008 Elsevier B.V. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Frank SJ; Fuchs SY
  • Start Page

  • 785
  • End Page

  • 794
  • Volume

  • 1782
  • Issue

  • 12