Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome.

Academic Article


  • OBJECTIVE: In preclinical reports, restriction of dietary methionine intake was shown to enhance metabolic flexibility, improve lipid profiles, and reduce fat deposition. The present report is the outcome of a "proof of concept" study to evaluate the efficacy of dietary methionine restriction (MR) in humans with metabolic syndrome. METHODS: Twenty-six obese subjects (six male and 20 female) meeting criteria for metabolic syndrome were randomized to a diet restricted to 2 mg methionine/kg body weight per day and were provided capsules containing either placebo (n = 12) or 33 mg methionine/kg body weight per day (n = 14). Energy expenditure, body composition, insulin sensitivity, and biomarkers of metabolic syndrome were measured before and after 16 wk on the respective diets. RESULTS: Insulin sensitivity and biomarkers of metabolic syndrome improved comparably in both dietary groups. Rates of energy expenditure were unaffected by the diets, but dietary MR produced a significant increase in fat oxidation (MR, 12.1 ± 6.0% increase; control, 8.1 ± 3.3% decrease) and reduction in intrahepatic lipid content (MR liver/spleen attenuation ratio, 8.1 ± 3.3% increase; control ratio, 2.2 ± 2.1% increase) that was independent of the comparable reduction in weight and adiposity that occurred in both groups. CONCLUSIONS: Sixteen weeks of dietary MR in subjects with metabolic syndrome produced a shift in fuel oxidation that was independent of the weight loss, decreased adiposity, and improved insulin sensitivity that was common to both diets.
  • Authors


  • Adipose Tissue, Biomarkers, Body Composition, Cohort Studies, Cystine, Diet, Dietary Fats, Double-Blind Method, Energy Metabolism, Fats, Female, Glucose, Humans, Insulin Resistance, Kinetics, Liver, Male, Metabolic Syndrome, Methionine, Middle Aged, Obesity, Oxidation-Reduction, Waist Circumference
  • Digital Object Identifier (doi)

    Author List

  • Plaisance EP; Greenway FL; Boudreau A; Hill KL; Johnson WD; Krajcik RA; Perrone CE; Orentreich N; Cefalu WT; Gettys TW
  • Start Page

  • E836
  • End Page

  • E840
  • Volume

  • 96
  • Issue

  • 5