Effect of weight reduction on resting energy expenditure, substrate utilization, and the thermic effect of food in moderately obese women.

Academic Article


  • It is not known whether the decrease in the thermic effect of food (TEF) in obesity is a consequence of obesity or a factor contributing to the development of obesity. The resting energy expenditure (REE) of 24 obese, nondiabetic, postmenopausal women was 5481 +/- 110 kJ/24 h (1310 +/- 26.4 kcal/24 h). After weight loss (12.7 +/- 0.45 kg) the REE was significantly decreased (4858 +/- 94 kJ/24 h, or 1161 +/- 22.4 kcal/24 h) and equivalent to the REE of 4866 +/- 119 kJ/24 h (1163 +/- 28.5 kcal/24 h) in 24 never-obese, postmenopausal women. The TEF, expressed as a percentage of the calories ingested, was 8.2 +/- 0.50% for obese subjects, 8.7 +/- 0.57% for postobese subjects, and 9.8 +/- 0.54% for never-obese subjects. Compared with never-obese subjects, the TEF was significantly reduced in obese subjects (P = 0.043) and remained unchanged after weight loss (P = 0.341). These findings indicate that the lower TEF in the obese subjects is uncorrected by weight loss, and thus it is a contributor to obesity rather than a consequence of obesity.
  • Keywords

  • Aged, Analysis of Variance, Basal Metabolism, Blood Glucose, Body Composition, Body Temperature Regulation, Carbohydrate Metabolism, Eating, Energy Intake, Epinephrine, Female, Humans, Insulin, Lipid Metabolism, Middle Aged, Obesity, Oxidation-Reduction, Proteins, Weight Loss
  • Digital Object Identifier (doi)

    Author List

  • Nelson KM; Weinsier RL; James LD; Darnell B; Hunter G; Long CL
  • Start Page

  • 924
  • End Page

  • 933
  • Volume

  • 55
  • Issue

  • 5