Different immune cells mediate mechanical pain hypersensitivity in male and female mice

Academic Article


  • A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Sorge RE; Mapplebeck JCS; Rosen S; Beggs S; Taves S; Alexander JK; Martin LJ; Austin JS; Sotocinal SG; Chen D
  • Start Page

  • 1081
  • End Page

  • 1083
  • Volume

  • 18
  • Issue

  • 8