Use of recombinant bone morphogenetic protein 2 in free flap reconstruction for osteonecrosis of the mandible.

Academic Article


  • PURPOSE: Osteoradionecrosis of the mandible is a debilitating consequence of radiation therapy for head-and-neck malignancy. It can result in pain, bone exposure, fistula formation, and pathologic fracture. Recombinant human bone morphogenetic protein 2 (rhBMP-2) has shown promise in reconstruction of bone defects. The purpose of this study is to determine whether the addition of rhBMP-2 at the union of vascularized bone and native bone improves surgical outcomes in patients with osteonecrosis of the mandible. MATERIALS AND METHODS: This study was a retrospective analysis of patients who were treated between 2006 and 2010 for osteonecrosis of the mandible. Patients requiring definitive reconstruction after failure of a course of conservative management were included. Patients were divided into 2 cohorts depending on whether rhBMP-2 was used during the reconstruction. The primary outcome measure was defined as stable mandibular union. RESULTS: Seventeen patients were included. The development of malunion was similar in both groups (13% for rhBMP-2 group vs 11% for non-rhBMP-2 group). Infectious complications were similar between the groups (25% in rhBMP-2 group vs 56% in non-rhBMP-2 group, P = .33). The rates of hardware removal were similar for the 2 groups (33% in non-rhBMP-2 group vs 25% in rhBMP-2 group, P = .10). No cancer recurrences were observed in patients receiving rhBMP-2. CONCLUSIONS: The use of rhBMP-2 is safe in free flap reconstruction of the mandible, but its ability to significantly improve patient outcomes, as measured by rates of malunion, reoperation, or infection, is still unknown.
  • Keywords

  • Bone Morphogenetic Protein 2, Bone Plates, Bone Transplantation, Carcinoma, Squamous Cell, Cohort Studies, Device Removal, Female, Follow-Up Studies, Free Tissue Flaps, Head and Neck Neoplasms, Humans, Male, Mandible, Mandibular Diseases, Middle Aged, Osteoradionecrosis, Osteotomy, Postoperative Complications, Recombinant Proteins, Reconstructive Surgical Procedures, Retrospective Studies, Skin Transplantation, Surgical Wound Dehiscence, Surgical Wound Infection, Transforming Growth Factor beta, Treatment Outcome, Wound Healing
  • Digital Object Identifier (doi)

    Author List

  • Sweeny L; Lancaster WP; Dean NR; Magnuson JS; Carroll WR; Louis PJ; Rosenthal EL
  • Start Page

  • 1991
  • End Page

  • 1996
  • Volume

  • 70
  • Issue

  • 8