The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis

Academic Article

Abstract

  • This study investigates the association of CRP (C-reactive protein) single-nucleotide polymorphisms (SNPs) with plasma CRP levels and radiographic severity in African Americans with early and established rheumatoid arthritis (RA). Using a cross-sectional case-only design, CRP SNPs were genotyped in two independent sets of African Americans with RA: Consortium for the Longitudinal Evaluation of African Americans with RA (CLEAR 1) and CLEAR 2. Radiographic data and CRP measurements were available for 294 individuals from CLEAR 1 (median (interquartile range (IQR) 25–75) disease duration of 1 (0.6–1.6) year) and in 407 persons from CLEAR 2 (median (IQR 25–75) disease duration of 8.9 (3.5–17.7) years). In CLEAR 1, in adjusted models, the minor allele of rs2808630 was associated with total radiographic score (incident rate ratio 0.37 (95% confidence interval (CI) 0.19–0.74), P-value=0.0051). In CLEAR 2, the minor allele of rs3093062 was associated with increased plasma CRP levels (P-value=0.002). For each rs3093062 minor allele, the plasma CRP increased by 1.51 (95% CI 1.15–1.95) mg dl-1 when all the other covariates remained constant. These findings have important implications for assessment of the risk of joint damage in African Americans with RA.Genes and Immunity advance online publication, 30 July 2015; doi:10.1038/gene.2015.24.
  • Digital Object Identifier (doi)

    Author List

  • Danila MI; Westfall AO; Raman K; Chen L; Reynolds RJ; Hughes LB; Arnett DK; McGwin G; Szalai AJ; van der Heijde DM