Composite B-cell and T-cell lymphoma arising 24 years after nodular lymphocyte predominant Hodgkin's disease.

Academic Article


  • Twenty-four years after apparently successful treatment for nodular lymphocyte predominant Hodgkin's disease (nLPHD), a 41-year old male developed "B" symptoms and extensive adenopathy. A right axillary lymph node biopsy showed two distinct regions including (1) histiocyte-rich B-cell lymphoma and (2) diffuse small T-cell lymphoma. A clonal rearrangement of the gene for the T-cell receptor beta chain confirmed the presence of a T-cell neoplasm, and this was further confirmed by selective polymerase chain reaction (PCR) on this morphologic zone. PCR on the morphologic B-cell lymphoma confirmed the presence of an immunoglobulin gene rearrangement. These two regions were separated by a less-defined zone containing a mixture of small CD57 positive T lymphocytes, small B lymphocytes, and rare lymphocytic and histiocytic (L&H) cells, highly suggestive of recurrent LPHD. The development of composite B-cell and T-cell lymphoma in this patient raises the speculation that nLPHD may be a neoplasm of lymphoid cells, which can differentiate in both B- and T-cell directions, with the "L&H" cells constituting their B-cell progeny.
  • Authors

    Published In


  • Adolescent, Adult, Biopsy, Flow Cytometry, Fluorescent Antibody Technique, Indirect, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Hodgkin Disease, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymph Nodes, Lymphoma, B-Cell, Lymphoma, Non-Hodgkin, Lymphoma, T-Cell, Male, Polymerase Chain Reaction, Reed-Sternberg Cells
  • Author List

  • Hancock JC; Wells A; Halling KC; Tilashalski K; Conner MG; Johns C; Listinsky CM
  • Start Page

  • 23
  • End Page

  • 34
  • Volume

  • 3
  • Issue

  • 1