Adult, Aged, Androstadienes, Apoptosis, Arthritis, Rheumatoid, Cell Survival, Cells, Cultured, Enzyme Inhibitors, Fibroblasts, Humans, In Situ Nick-End Labeling, Middle Aged, NF-kappa B, Osteoarthritis, Knee, Phosphorylation, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Synovial Membrane, Transfection, Tumor Necrosis Factor-alpha, Wortmannin