Enzyme-mediated degradation of peptide-amphiphile nanofiber networks

Academic Article

Abstract

  • The use of a novel elastic nanofiber network to encapsulate dental pulp cells by self-assembly and interaction with cells through biological moieties were described. The properties of this network can easily tailored by employing various kinds of adhesive ligands, MMP-sensitive sequences and divalent ions. The nanofiber growth induced by divalent ions was investigated by dynamic light scattering (DLS) and circular dichroism (CD). The incorporation of an MMP-2 specific peptide sequence in the nanofiber results in cells-mediated proteolysis degradation of the network, enabling cell migration through the matrix and eventual remodeling of the matrix with natural ECM.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Jun HW; Yuwono V; Paramonov SE; Hartgerink JD
  • Start Page

  • 2612
  • End Page

  • 2617
  • Volume

  • 17
  • Issue

  • 21