Association of high viral load and abnormal liver function with high aflatoxin B 1-albumin adduct levels in HIV-positive Ghanaians: Preliminary observations

Academic Article

Abstract

  • We examined the association between certain clinical factors and aflatoxin B 1-albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg -1 albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR = 2.84; 95% CI =1.17-7.78) and higher direct bilirubin levels (OR = 5.47; 95% CI = 1.03-22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression. © 2011 Taylor & Francis.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Jolly PE; Shuaib FM; Jiang Y; Preko P; Baidoo J; Stiles JK; Wang JS; Phillips TD; Williams JH
  • Start Page

  • 1224
  • End Page

  • 1234
  • Volume

  • 28
  • Issue

  • 9