The low-velocity impact response of plain autoclaved aerated concrete (AAC) and carbon fiber reinforced polymer (CFRP)/AAC sandwich panels has been investigated. The structural sandwich panels composed of CFRP/AAC combinations have shown excellent characteristics in terms of high strength and high stiffness-weight ratios. In addition to having adequate flexural and shear properties, the behavior of CFRP/AAC sandwich panels needs to be investigated when subjected to impact loading. During service, the structural members in building structures are subject to impact loading that varies from object-caused impacts, blasts due to explosions, and high-velocity impact of debris during tornados, hurricanes, and storms. Low-velocity impact (LVI) testing serves as a means to quantify the allowable impact energy the structure can withstand, and to assess the typical failure modes encountered during this type of loading. The objectives of this paper are: to study the response of plain AAC and CFRP/AAC sandwich structures to low-velocity impact and to assess the damage performance of the panels; to study the effect of CFRP laminates on the impact response of CFRP/AAC panels; and to study the effect of the processing method (hand lay-up versus vacuum assisted resin transfer molding) and panels' stiffness on the impact response of hybrid panels. Impact testing was conducted using an Instron drop-tower testing machine. Experimental results showed a significant influence of CFRP laminates on energy absorption and peak loads of CFRP/AAC panels. A theoretical analysis was conducted to predict the energy absorbed by CFRP/AAC sandwich panels using the energy balance model. Results found were in good accordance with the experimental data. © Copyright 2014, American Concrete Institute. All rights reserved.