Nanomechanical properties of electrospun composite scaffolds based on polycaprolactone and hydroxyapatite

Academic Article

Abstract

  • Fibrous nanocomposite scaffolds were electrospun from dispersions of hydroxyapatite nanoparticles (nanoHA) in polycaprolactone (PCL) with varying nanoHA contents (from 0% to 50% by weight). Such scaffolds were produced to mimic the nano-features of the extracellular matrix (ECM) for natural bone tissue regeneration. NanoHA was found to be well dispersed in the PCL fibers up to the addition of 30 wt%, whereas beads and agglomeration of HA particles was observed above this nanoHA concentration. The structural and morphological characterizations were evaluated by scanning electron microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), and X-ray Diffraction (XRD). The average fiber diameter decreased with increased nanoHA concentration. The nanomechanical properties of the as-spun fibrous scaffolds as well as pressure-consolidated (pelletized) composites were evaluated by nanoindentation. Elastic modulus increased with increasing HA content, but was especially pronounced for 40-50% HA content where the indenter tip is more likely to probe agglomerated HA particles. Copyright © 2009 American Scientific Publishers.
  • Digital Object Identifier (doi)

    Author List

  • Tyagi P; Catledge SA; Stanishevsky A; Thomas V; Vohra YK
  • Start Page

  • 4839
  • End Page

  • 4845
  • Volume

  • 9
  • Issue

  • 8