Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

Academic Article


  • Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Vitturi DA; Chen CS; Woodcock SR; Salvatore SR; Bonacci G; Koenitzer JR; Stewart NA; Wakabayashi N; Kensler TW; Freeman BA
  • Start Page

  • 25626
  • End Page

  • 25637
  • Volume

  • 288
  • Issue

  • 35