In vitro studies on the effect of physical cross-linking on the biological performance of aliphatic poly(urethane urea) for blood contact applications

Academic Article

Abstract

  • The effect of physical cross-linking in candidate cycloaliphatic and hydrophobic poly(urethane urea) (4,4′-methylenebis(cyclohexylisocyanate), H12MDI/hydroxy-terminated polybutadiene, HTPBD/hexamethylene-diamine, HDA) and poly(ether urethane urea)s (H12MDI/HTPBD-PTMG/HDA) on the in vitro calcification and blood-material interaction was studied. All the candidate poly(urethane urea)s and poly(ether urethane urea)s elicit acceptable hemolytic activity, cytocompatibility, calcification, and blood compatibility in vitro. The studies on blood-material interaction reveal that the present poly(urethane urea)s are superior to polystyrene microtiter plates which were used for the studies on blood-material interaction. The present investigation reveals the influence of physical cross-link density on biological interaction differently with poly(urethane urea) and poly(ether urethane urea)s. The higher the physical cross-link density in the poly-(urethane urea)s, the higher the calcification and consumption of WBC in whole blood. On the other hand, the higher the physical cross-link density in the poly(ether urethane urea)s, the lesser the calcification and consumption of WBC in whole blood. However a reverse of the above trend has been observed with the platelet consumption in the poly(urethane urea)s and poly(ether urethane urea)s.
  • Authors

    Published In

  • Biomacromolecules  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 8895712
  • Author List

  • Thomas V; Kumari TV; Jayabalan M
  • Start Page

  • 588
  • End Page

  • 596
  • Volume

  • 2
  • Issue

  • 2