Modification of the recovery period after lateral hypothalamic lesions

Academic Article


  • Following lateral hypothalamic (LH) lesions animals become aphagic and adipsic. However, if adequately nursed, they may recover eating and drinking behaviors. The authors are presently demonstrating that administration of pancreatic glucodynamic hormones modifies this recovery period. For 5 days prior to surgery 21 male, adult rats were s.c. injected with either 0.1 mg of glucacon (every 6 hr), 3 U of Semilente Insulin (every 12 hr), or isotonic saline (every 6 hr). During this period, the rats were fed an amount of food equal to the average amount consumed during the previous 5 days, thus maintaining body weight. Injections were discontinued 24 hours prior to surgery. Bilateral electrolytic lesions of the LH were then made. Resumption of feeding and drinking occurred in 3.8 days after saline, 1.4 days after insulin, and 6 days after glucagon. The results are not due to the residual accumulation of the hormones. They may be due to the modification of norepinephrine (NE) synthesis. Insulin decreases both tyrosine hydroxylase and dopamine β hydroxylase. α Methyl p tyrosine, which inhibits NE synthesis, also shortens LH recovery. Glucagon may inhibit recovery of NE mediated feeding behavior. Neurochemical research is needed to support this contention.
  • Authors

    Published In

  • The FASEB Journal  Journal
  • Author List

  • Balagura S; Harrell L; Ralph T
  • Start Page

  • 926
  • Volume

  • 32
  • Issue

  • 3 I