Intraocular pressure-raising potential of 1.0% Rimexolone in patients responding to corticosteroids

Academic Article


  • Objective: To compare the intraocular pressure (IOP) elevating potential of 1.0% rimexolone and 0.1% fluorometholone alcohol ophthalmic suspensions in patients known to have responded to corticosteroids. Design: In a double-masked, randomized, single-eye, crossover protocol, corticosteroid responsiveness initially was verified in 40 asymptomatic known steroid responders by challenge with either 0.1% dexamethasone sodium phosphate or 1.0% prednisolone acetate for up to 6 weeks. After a 1-month medication washout, subjects randomly received either rimexolone or fluorometholone for 6 weeks. Medications were again discontinued for 1 month, and subjects then received the alternate drug for 6 weeks. Results: There was no significant difference between rimexolone and fluorometholone in the number of subjects demonstrating a 10-mm Hg increase in IOP or in the mean number of weeks required to achieve a 10-mm Hg response. Responses occurred in significantly more subjects receiving dexamethasone sodium phosphate (P=.001) or prednisolone acetate (P<.001) and in a significantly shorter interval than in subjects receiving rimexolone. Conclusions: Rimexolone has a low IOP-elevating potential, comparable to that of fluorometholone and less than that of dexamethasone sodium phosphate and prednisolone acetate.
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    Published In

    Digital Object Identifier (doi)

    Author List

  • Leibowitz HM; Bartlett JD; Rich R; McQuirter H; Stewart R; Assil K
  • Start Page

  • 933
  • End Page

  • 937
  • Volume

  • 114
  • Issue

  • 8