Targeting TGF-β1 and AKT signal on growth and metastasis of anaplastic thyroid cancer cell in vivo

Academic Article


  • OBJECTIVE: We have recently reported that therapies targeting TGF-β1 signaling were effective to prevent the anaplastic thyroid cancer (ATC) cell growth, but not the invasion. Phosphatidylinositol 3-kinase (PI3K)/AKT signaling are activated in ATC and play a major role in ATC invasion. Herein, we examined the effects of targeting TGF-β1 by shRNA in combination with pan-AKT inhibitor, MK-2206 on growth and metastasis of ATC xenografts implanted in severe combined immunodeficient mice.
  • Author List

  • Li Y; Chen D; Hao FY; Zhang KJ
  • Start Page

  • 2581
  • End Page

  • 2587
  • Volume

  • 20
  • Issue

  • 12