Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease

Academic Article


  • Tear secretion is regulated by the lacrimal functional unit consisting of afferent and efferent nerve innervation. The afferent arm consists of trigeminal nociceptors on the ocular surface and nasal mucosa. When stimulated by agonists, nicotinic acetylcholine receptors on nerve endings in the nose initiate a reflex arc resulting in instantaneous tear secretion. Pharmacologic nasal neural stimulation to increase endogenous tear production is a novel approach to treating dry eye disease.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Pflugfelder SC; Cao A; Galor A; Nichols KK; Cohen NA; Dalton M
  • Start Page

  • 58
  • End Page

  • 64
  • Volume

  • 25