Recent studies from a number of model organisms have indicated that aging is mediated by genetic and epigenetic mechanisms. Few recent experiments also demonstrate that modulation in the chromatin modifying agents also affect the life span of an organism, and these chromatin modifications have a metabolic linkage. Further, the aging clock of an organism can be reset by reversal of aging. Aged cells can be reprogrammed to young ones by direct reprogramming by epigenetic rejuvenation or young cells can be obtained from them by passing through a dedifferentiated state. In the present report, we discuss the chromatin organization and its changes during aging. Further, we discuss how metabolic reprogramming can be linked to aging reversals to obtain epigenetic rejuvenation and challenges ahead.