Safe and Effective Use of Imatinib to Treat Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia During Pregnancy

Academic Article


  • Philadelphia chromosome positive (Ph+) B cell acute lymphoblastic leukemia (ALL) is extremely rare in pregnancy. Although the use of tyrosine kinase inhibitors (TKIs) has significantly improved outcomes of patients with Ph+ ALL, its use during pregnancy is not recommended due to the risk of fetal malformations. There are limited data on the use of TKIs during pregnancy and its long-term effects on the fetus. Within this context, we present a case of a 25-year-old woman diagnosed with Ph+ ALL during the third trimester and the safe and effective use of imatinib as treatment after failure of conventional chemotherapy.
  • Digital Object Identifier (doi)

    Author List

  • Ashraf S; Wolfson J; Vachhani P; Rangaraju S; Bachiashvili K; Bhatia R; Jamy O
  • Start Page

  • 617
  • End Page

  • 620
  • Volume

  • 11
  • Issue

  • 6