Vedolizumab Therapy in Refractory Enteropathy Associated With CVID.

Academic Article


  • Common variable immunodeficiency (CVID) is a disorder of typically adult-onset hypogammaglobulinemia in the absence of other known causes. Noninfectious gastrointestinal tract manifestations are common, and a subset of patients with CVID present with a severe enteropathy manifesting as severe malabsorption, weight loss, and diarrhea. A 63-year-old man presented with CVID and severe enteropathy who failed to improve with cytomegalovirus therapy, multiple empiric therapies, and corticosteroids. Vedolizumab infusions were initiated with a dramatic, rapid, and durable complete clinical response.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Johnson D; Lee G; Weber F
  • Start Page

  • e00721
  • Volume

  • 9
  • Issue

  • 1