Maintaining rigor in an online chemistry course is of the utmost importance to ensure students acquire equivalent knowledge when compared to an in-person, on-ground course. Multiple approaches can be employed to ensure online chemistry courses maintain rigor and academic integrity in the online chemistry classroom. Best practices regarding the structure of remote and online courses are discussed. Types of questions utilized in online assessments, assessment settings that discourage cheating, and the use of online proctoring will be shared. A variety of methodologies utilized, course structure, and strategies for maintaining rigor and academic integrity in introductory and general chemistry courses at multiple institutions will be presented.