The effect of the Standard American Diet on Iba-1 immunoreactivity in the spinal cord before and after peripheral inflammatory injury in rats

Academic Article


  • Background: A poor-quality diet may contribute to chronic levels of inflammation and alter susceptibility to pain via activation of immune cells. Methods: Here we examined the effect of a human-relevant Standard American Diet (SAD) prior to and following peripheral inflammatory injury. Results: SAD consumption significantly increased Iba-1 staining in the dorsal horn of the spinal cord in rats in the presence and absence of peripheral inflammatory injury. Conclusions: These data suggest that diet may predispose animals to an exacerbated immune response in the both presence and absence of injury. Diet may extend recovery times as a consequence of persistent immune cell activation and enhanced responses to injury.
  • Authors

    Published In

  • PharmaNutrition  Journal
  • Digital Object Identifier (doi)

    Author List

  • Strath LJ; Totsch SK; Quinn TL; Menard M; Philip George A; Lukens SL; Simmons J; Zhang Y; Sorge RE
  • Volume

  • 18