A study of elective genome sequencing and pharmacogenetic testing in an unselected population

Academic Article


  • Background: Genome sequencing (GS) of individuals without a medical indication, known as elective GS, is now available at a number of centers around the United States. Here we report the results of elective GS and pharmacogenetic panel testing in 52 individuals at a private genomics clinic in Alabama. Methods: Individuals seeking elective genomic testing and pharmacogenetic testing were recruited through a private genomics clinic in Huntsville, AL. Individuals underwent clinical genome sequencing with a separate pharmacogenetic testing panel. Results: Six participants (11.5%) had pathogenic or likely pathogenic variants that may explain one or more aspects of their medical history. Ten participants (19%) had variants that altered the risk of disease in the future, including two individuals with clonal hematopoiesis of indeterminate potential. Forty-four participants (85%) were carriers of a recessive or X-linked disorder. All individuals with pharmacogenetic testing had variants that affected current and/or future medications. Conclusion: Our study highlights the importance of collecting detailed phenotype information to interpret results in elective GS.
  • Digital Object Identifier (doi)

    Author List

  • Cochran M; East K; Greve V; Kelly M; Kelley W; Moore T; Myers RM; Odom K; Schroeder MC; Bick D
  • Volume

  • 9
  • Issue

  • 9