Systemic drug profiles of adult patients seen in an optometric outpatient setting were determined. The sample consisted of 502 subjects, of whom 214 were taking known medication, 267 were not taking drugs, and 21 subjects were taking unidentified medication. The most frequently used drugs and drug groups were identified and compared to a 1986 national survey that ranked the most frequently prescribed systemic medications. Drug distribution by age, sex, and race of the 22 most frequently prescribed drugs was determined. Implications for the ophthalmic practitioner are discussed.