Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: A case for neuroprotection

Academic Article


  • Aims: To determine the visual outcome following initiation of brimonidine therapy in glaucoma. Methods: 16 newly diagnosed previously untreated glaucoma patients were randomly assigned to either timalal 0.5% or brimanidine 0.2%. Visual acuity, contrast sensitivity (CS), visual fields, intraocular pressure (IOP), blaad pressure, and heart rate were evaluated at baseline and after 3 months. Results: IOP reduction was similar far both groups (p<0.05). Brimanidine improved CS; in the right eye at 6 and 12 cpd (p = 0.043, p = 0.017); in the left eye at 3 and 12 cpd (p = 0.044, p = 0.046). Timolol reduced CS at 18 cpd in the right eye (p = 0.041). There was no change in any other measured parameters. Conclusion: Glaucoma patients exhibit improved CS an initiation of brimanidine therapy.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Evans DW; Hosking SL; Gherghel D; Bartlett JD
  • Start Page

  • 1463
  • End Page

  • 1465
  • Volume

  • 87
  • Issue

  • 12