The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility

Academic Article

Abstract

  • The Kidd blood group locus encodes a urea transporter which is expressed on human red cells and in the kidney. This gene is located on chromosome 18q12, and evidence for linkage and association with type 1 diabetes mellitus has been reported. To investigate this further, the genetic basis for the blood group Jka/Jkb polymorphism was first determined by sequencing reverse-transcribed reticulocyte RNAs from Jk(a+b-) and Jk(a-b+) donors. The Jka/Jkb polymorphism was caused by a transition (G838A), resulting in a Asp280Asn amino acid substitution and an MnlI restriction fragment length polymorphism (RFLP). Using the MnlI RFLP, we found that the Jka/Jkb polymorphism was not in linkage disequilibrium with type 1 diabetes in 228 multiplex UK and US families tested.
  • Authors

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    Author List

  • Oliv├Ęs B; Merriman M; Bailly P; Bain S; Barnett A; Todd J; Cartron JP; Merriman T
  • Start Page

  • 1017
  • End Page

  • 1020
  • Volume

  • 6
  • Issue

  • 7