Chaotic license for genetic instability and cancer

Academic Article


  • Replication initiation factors are essential for cell proliferation and thus are not expected to be disrupted in cancers. Challenging this notion, a new study in mice shows that a hypomorphic mutation in the gene encoding the replication initiation factor Mcm4 leads to genetic instability and predisposes to mammary adenocarcinomas. © 2006 Nature Publishing Group.
  • Authors

    Published In

  • Nature Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Dutta A
  • Start Page

  • 10
  • End Page

  • 11
  • Volume

  • 39
  • Issue

  • 1