Confirming glycemic status in the Diabetes Prevention Program: implications for diagnosing diabetes in high risk adults.

Academic Article


  • AIMS: To examine the ability of fasting plasma glucose (FPG) and/or 2-h glucose to confirm diabetes and to determine the proportion of participants with HbA1c ≥6.5%. METHODS: Diabetes confirmation rates were calculated after a single elevated FPG and/or 2-h glucose on an oral glucose tolerance test (OGTT) using a confirmatory OGTT performed within 6 weeks. RESULTS: 772 (24%) participants had elevated FPG or 2-h glucose on an OGTT that triggered a confirmation visit. There were 101 triggers on FPG alone, 574 on 2-h glucose alone, and 97 on both. Only 47% of participants who triggered had confirmed diabetes. While the confirmation rate for FPG was higher than that for 2-h glucose, the larger number of 2-h glucose triggers resulted in 87% of confirmed cases triggering on 2-h glucose. Confirmation rates increased to 75% among persons with FPG ≥126 mg/dl and HbA1c ≥6.5%. CONCLUSIONS: Only half of the persons with elevated FPG and IGT were subsequently confirmed to have diabetes. At current diagnostic levels, more persons trigger on 2-h glucose than on FPG, but fewer of these persons have their diagnoses confirmed. In individuals with FPG ≥126 mg/dl and HbA1c ≥6.5%, the confirmation rate was increased.
  • Authors


  • Adult, Aged, Blood Glucose, Cohort Studies, Diabetes Mellitus, Type 2, Fasting, Female, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Hyperglycemia, Male, Mass Screening, Middle Aged, Practice Guidelines as Topic, Predictive Value of Tests, Risk
  • Digital Object Identifier (doi)

    Pubmed Id

  • 22180003
  • Author List

  • Christophi CA; Resnick HE; Ratner RE; Temprosa M; Fowler S; Knowler WC; Shamoon H; Barrett-Connor E; Kahn SE; Diabetes Prevention Program Research Group
  • Start Page

  • 150
  • End Page

  • 157
  • Volume

  • 27
  • Issue

  • 2